Surfactant protein A

surfactant, pulmonary-associated protein A1
Identifiers
Symbol SFTPA1
Alt. symbols SFTP1
Entrez 6435
HUGO 10798
OMIM 178630
RefSeq NM_005411
UniProt Q8IWL2
Other data
Locus Chr. 10 q22.3
surfactant, pulmonary-associated protein A2B
Identifiers
Symbol SFTPA2B
Entrez 6436
HUGO 10799
OMIM 178642
RefSeq NM_006926
UniProt Q8IWL1
Other data
Locus Chr. 10 q22.3

Surfactant protein A is an innate immune system collectin.

Contents

During Parturition

The role of Surfactant protein A (or SP-A) in childbirth is indicated in studies with mice.[1] Mice which gestate for 19 days typically show signs of SP-A in amniotic fluid at around 16 days. If SP-A is injected into the uterus at 15 days, mice typically deliver early. Inversely, an SP-A inhibitor injection causes notable delays in birth.

The presence of Surfactant Protein A seemed to trigger an inflammatory response in the uterus of the mice, but later studies found an anti-inflammatory response in humans.[2] In fact, the level of SP-A in a human uterus typically decreases during labor.

See also

External links

References

  1. ^ Condon, Jennifer C.; Jeyasuria, Pancharatnam; Faust, Julie M.; Mendelson, Carole R. (2004). "Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition". Proceedings of the National Academy of Sciences 101 (14): 4978–83. doi:10.1073/pnas.0401124101. JSTOR 3371804. PMC 387359. PMID 15044702. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=387359. 
  2. ^ Lee, Deug-Chan; Romero, Roberto; Kim, Chong Jai; Chaiworapongsa, Tinnakorn; Tarca, Adi L.; Lee, JoonHo; Suh, Yeon-Lim; Mazaki-Tovi, Shali et al. (2010). "Surfactant Protein-A as an Anti-Inflammatory Component in the Amnion: Implications for Human Pregnancy". The Journal of Immunology 184 (11): 6479–91. doi:10.4049/jimmunol.0903867. PMC 3103775. PMID 20439915. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3103775.